Genoa is the capital city of the Liguria region and the sixth-largest city in Italy. Genoa has historically been one of the most important ports on the Mediterranean: it is currently the busiest in Italy and in the Mediterranean Sea and the twelfth busiest in the Euopean Union. Part of the old town of Genoa was inscribed on the World Heritage List (UNESCO) in 2006 as “Genoa: Le Strade Nuove and the system of the Palazzi dei Rolli”. The city is highly committed to foster a new model of sustainable development through an innovative initiative investing in a smarter resilient future. In the main planning documents of the city such as the Urban Masterplan, SUMP, SECAP (formerly SEAP), and the Lighthouse City Strategy on resilience and sustainable development, there are many suggested measures to facilitate the transition to an urban regenerated territory. Both mitigation and adaptation measures are also forseen to face climate change effects and improve people's wellbeing by following a new path of development for a holistic resilience strategy of the city.